Replacement of Stoichiometric DDQ with a Low Potential o-Quinone Catalyst Enabling Aerobic Dehydrogenation of Tertiary Indolines in Pharmaceutical Intermediates
Bao Li, Alison E. Wendlandt, Shannon S. Stahl*
*Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States, Email: stahlchem.wisc.edu
B. Li, A. E. Wendlandt, S. S. Stahl, Org. Lett., 2019, 21, 1176-1181.
DOI: 10.1021/acs.orglett.9b00111 (free Supporting Information)
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A transition-metal/quinone complex is an effective catalyst for aerobic dehydrogenation of 3° indolines to the corresponding indoles. The utility of the method is demonstrated in the synthesis of key intermediates to pharmaceutically important molecules.
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