Vanadium-Catalyzed Coupling of Allenols with Electrophilic Halide Sources for the Formation of α-Halo-α',β'-unsaturated Ketones
Barry M. Trost*, Jacob S. Tracy, Tas Yusoontorn
*Department of Chemistry, Stanford University, 333 Campus Drive, Stanford, California 94305, United States, Email: bmtroststanford.edu
B. M. Trost, J. S. Tracy, T. Yusoontorn, Org. Lett., 2019, 21, 1207-1211.
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A vanadium-catalyzed coupling of allenylic alcohols with electrophilic halide sources provides α-halo-α',β'-unsaturated ketones. Fluorine, chlorine, and bromine electrophiles can be utilized, and the resulting products can give rise to the introduction of nitrogen, oxygen, sulfur, and iodine nucleophiles α to the ketone through substitution chemistry.
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