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Oxalic Diamides and tert-Butoxide: Two Types of Ligands Enabling Practical Access to Alkyl Aryl Ethers via Cu-Catalyzed Coupling Reaction

Zhixiang Chen, Yongwen Jiang, Li Zhang, Yinlong Guo, Dawei Ma*

*Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China, Email:

Z. Chen, Y. Jiang, L. Zhang, Y. Guo, D. Ma, J. Am. Chem. Soc., 2019, 141, 3541-3549.

DOI: 10.1021/jacs.8b12142

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Two types of ligands promote Cu-catalyzed alkoxylations of (hetero)aryl halides to provide alkyl aryl ethers. In case of coupling with aryl chlorides and bromides, two oxalic diamides serve as the powerful ligands. In addition, tert-butoxide enables a Cu-catalyzed alkoxylation of aryl iodides at room temperature.

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Key Words

Ullmann Synthesis, Aryl Ethers

ID: J48-Y2019