Organic Chemistry Portal



Palladium-Catalyzed Methylation of Aryl, Heteroaryl, and Vinyl Boronate Esters

Alexander M. Haydl, John F. Hartwig*

*Department of Chemistry, University of California, Berkeley, California 94720, United States, Email:

A. M. Haydl, J. F. Hartwig, Org. Lett., 2019, 21, 1337-1341.

DOI: 10.1021/acs.orglett.9b00025


A Pd-catalyzed direct methylation of aryl, heteroaryl, and vinyl boronate esters with iodomethane occurs with a remarkably broad scope and is suitable for late-stage derivatization of biologically active compounds.

see article for more examples

Key Words

alkylation (arenes, alkenes)

ID: J54-Y2019