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Highly Selective Reductive Cross-Amination between Aniline or Nitroarene Derivatives and Alkylamines Catalyzed by Polysilane-Immobilized Rh/Pt Bimetallic Nanoparticles

Aya Suzuki, Hiroyuki Miyamura, Shū Kobayashi*

*Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Email:

A. Suzuki, H. Miyamura, S. Kobayashi, Synlett, 2019, 30, 387-392.

DOI: 10.1055/s-0037-1611341 (free Supporting Information)

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A reductive cross-amination between imine intermediates generated through partial hydrogenation of aniline or nitroarene derivatives and alkylamines provides N-alkylated cyclohexylamine derivatives in the presence of heterogeneous Rh/Pt bimetallic nanoparticles under mild conditions. The catalyst was recovered and reused for five runs, keeping high activity.

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Key Words

reductive amination, amines, arene hydrogenation, heterogeneous catalyst, metal nanoparticle, hydrogen

ID: J72-Y2019