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Room Temperature Deoxyfluorination of Benzaldehydes and α-Ketoesters with Sulfuryl Fluoride and Tetramethylammonium Fluoride

Patrick R. Melvin, Devin M. Ferguson, Sydonie D. Schimler, Douglas C. Bland, Melanie S. Sanford*

*Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States, Email:

P. R. Melvin, D. M. Ferguson, S. D. Schimler, D. C. Bland, M. S. Sanford, Org. Lett., 2019, 21, 1350-1353.

DOI: 10.1021/acs.orglett.9b00054


The combination of sulfuryl fluoride and Me4NF enables a room temperature deoxyfluorination of a broad range of benzaldehydes and α-ketoesters.

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Key Words

difluorides, benzylfluorides

ID: J54-Y2019