Dinuclear Zinc-AzePhenol Catalyzed Asymmetric Aza-Henry Reaction of N-Boc Imines and Nitroalkanes under Ambient Conditions

Shanshan Liu, Wen-Chao Gao, Yu-Hang Miao, Min-Can Wang*

*The College of Chemistry and Molecular Engineering, Zhengzhou University, No. 75 Daxue Road, Zhengzhou, Henan 450052, P. R. China, Email: wangmincanzzu.edu.cn

S. Liu, W.-C. Gao, Y.-H. Miao, M.-C. Wang, J. Org. Chem., 2019, 84, 2654-2659.

DOI: 10.1021/acs.joc.8b02943

---

see article for more reactions

Abstract

A dinuclear zinc-AzePhenol complex catalyzes an asymmetric aza-Henry reaction of N-Boc imines and nitroalkanes to provide various nitroamines in good yields with excellent enantioselectivities and high diasteroselectivity. The method offers operational simplicity and mild reaction conditions.

see article for more examples

---

---

Key Words

Henry reaction, nitro compounds

---

ID: J42-Y2019