Organocatalyzed Aerobic Oxidation of Aldehydes to Acids
Peng-Fei Dai, Jian-Ping Qu*, Yan-Biao Kang*
*Nanjing Tech University, Nanjing 211816; University of Science and Technology of China, Hefei, Anhui 230026, China, Email: ias_jpqunjtech.edu.cn, ybkangustc.edu.cn
P.-F. Dai, J.-P. Qu, Y.-B. Kang, Org. Lett., 2019, 21, 1393-1396.
DOI: 10.1021/acs.orglett.9b00101 (free Supporting Information)
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An aerobic oxidation of a wide range of aldehydes to carboxylic acids in both organic solvent and water under mild conditions is catalyzed by 5 mol % N-hydroxyphthalimide (NHPI) as the organocatalyst in the presence of oxygen as the sole oxidant. No transition metals or hazardous oxidants or cocatalysts were involved.
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