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Organocatalyzed Aerobic Oxidation of Aldehydes to Acids

Peng-Fei Dai, Jian-Ping Qu*, Yan-Biao Kang*

*Nanjing Tech University, Nanjing 211816; University of Science and Technology of China, Hefei, Anhui 230026, China, Email:,

P.-F. Dai, J.-P. Qu, Y.-B. Kang, Org. Lett., 2019, 21, 1393-1396.

DOI: 10.1021/acs.orglett.9b00101

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An aerobic oxidation of a wide range of aldehydes to carboxylic acids in both organic solvent and water under mild conditions is catalyzed by 5 mol % N-hydroxyphthalimide (NHPI) as the organocatalyst in the presence of oxygen as the sole oxidant. No transition metals or hazardous oxidants or cocatalysts were involved.

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Key Words

oxidation of aldehydes, organocatalysis, green chemistry, oxygen

ID: J54-Y2019