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N-Heterocyclic Carbene-Catalyzed Decarboxylative Alkylation of Aldehydes

Takuya Ishii, Yuki Kakeno, Kazunori Nagao*, Hirohisa Ohmiya*

*Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan, Email: nkazunorip.kanazawa-u.ac.jp, ohmiyap.kanazawa-u.ac.jp

T. Ishii, Y. Kakeno, K. Nagao, H. Ohmiya, J. Am. Chem. Soc., 2019, 141, 3854-3858.

DOI: 10.1021/jacs.9b00880 (free Supporting Information)



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Abstract

A mild and transition-metal-free decarboxylative coupling of aryl aldehydes and tertiary or secondary alkyl carboxylic acid-derived redox-active esters is catalyed by a N-heterocyclic carbene to provide aryl alkyl ketones.


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Key Words

ketones, organocatalysis


ID: J48-Y2019