Metal-Free Catalytic Synthesis of Thiocarbamates Using Sodium Sulfinates as the Sulfur Source
Pengli Bao, Leilei Wang, Huilan Yue, Yun Shao, Jiangwei Wen, Daoshan Yang, Xiaohui Zhao, Hua Wang, Wei Wei*
*School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong, China,
Email: weiweiqfnu
163.com
P. Bao, L. Wang, H. Yue, Y. Shao, J. Wen, D. Yang, Y. Zhao, H. Wang, W. Wei, J. Org. Chem., 2019, 84, 2976-2983.
DOI: 10.1021/acs.joc.8b02844
see article for more reactions
Abstract
Molecular iodine catalyzes a facile and practical synthesis of thiocarbamates in good yields from readily available sodium sulfinates, isocyanides, and water. The present methodology offers favorable functional group tolerance and the use of odorless sodium sulfinates.
see article for more examples
proposed mechanism
Key Words
thiocarbamates, multicomponent reactions, oxygen
ID: J42-Y2019
