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Metal-Free Catalytic Synthesis of Thiocarbamates Using Sodium Sulfinates as the Sulfur Source

Pengli Bao, Leilei Wang, Huilan Yue, Yun Shao, Jiangwei Wen, Daoshan Yang, Xiaohui Zhao, Hua Wang, Wei Wei*

*School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong, China, Email:

P. Bao, L. Wang, H. Yue, Y. Shao, J. Wen, D. Yang, Y. Zhao, H. Wang, W. Wei, J. Org. Chem., 2019, 84, 2976-2983.

DOI: 10.1021/acs.joc.8b02844

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Molecular iodine catalyzes a facile and practical synthesis of thiocarbamates in good yields from readily available sodium sulfinates, isocyanides, and water. The present methodology offers favorable functional group tolerance and the use of odorless sodium sulfinates.

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proposed mechanism

Key Words

thiocarbamates, multicomponent reactions, oxygen

ID: J42-Y2019