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Structure Ligation Relationship of Amino Acids for the Amination Cross-Coupling Reactions

Gargi Nikhil Vaidya, Arif Khan, Hansa Verma, Sanjeev Kumar, Dinesh Kumar*

*Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER) − Ahmadabad, Palaj, Gandhinagar 382355, Gujarat, India, Email:

G. N. Vaidya, A. Khan, H. Verma, S. Kumar, D. Kumar, J. Org. Chem., 2019, 84, 3004-3010.

DOI: 10.1021/acs.joc.8b03214

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L-methionine ligated Cu catalyzes C-N cross-couplings of aromatic as well as aliphatic amines including tautomerizable N-heteroarenes. The amino, carboxy, and sulfide functions were critical for their ligation efficiency.

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Key Words

indoles, N-arylation

ID: J42-Y2019