Perhydrolysis in Ethereal H₂O₂ Mediated by MoO₂(acac)₂: Distinct Chemoselectivity between Ketones, Ketals, and Epoxides

Xiaosheng An, Qinghong Zha, Yikang Wu*

*State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China, Email: yikangwumail.sioc.ac.cn

X. An, Q. Zha, Y. Wu, Org. Lett., 2019, 21, 1542-1546.

DOI: 10.1021/acs.orglett.9b00425

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Abstract

Ketones, ketals, and epoxides can be converted to the corresponding hydroperoxides in high yields and with high chemoselectivity by reaction with ethereal H₂O₂ in the presence of a catalytic amount of MoO₂(acac)₂.

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A Broadly Applicable Mild Method for the Synthesis of gem-Diperoxides from Corresponding Ketones or 1,3-Dioxolanes

Y. Li, H.-D. Hao, Q. Zhang, Y. Wu, Org. Lett., 2009, 11, 1615-1618.

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Key Words

peroxides, hydrogen peroxide

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ID: J54-Y2019