Catalytic Strategy for Regioselective Arylethylamine Synthesis
Allyson J. Boyington, Ciaran P. Seath, Avery M. Zearfoss, Zihao Xu, Nathan T. Jui*
*Department of Chemistry and Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, United States, Email: njuiemory.edu
A. J. Boyington, C. P. Seath, A. M. Zearfoss, Z. Xu, N. T. Jui, J. Am. Chem. Soc., 2019, 141, 4147-4153.
DOI: 10.1021/jacs.9b01077 (free Supporting Information)
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A unique combination of organic catalysts promotes the transfer of electrons and hydrogen atoms in a mild, modular, and practical direct hydroarylation of vinyl amine derivatives with a wide range of aryl halides (including aryl chlorides). This general and highly chemoselective protocol delivers a broad range of arylethylamine products with complete regiocontrol.
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