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Catalytic Strategy for Regioselective Arylethylamine Synthesis

Allyson J. Boyington, Ciaran P. Seath, Avery M. Zearfoss, Zihao Xu, Nathan T. Jui*

*Department of Chemistry and Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, United States, Email:

A. J. Boyington, C. P. Seath, A. M. Zearfoss, Z. Xu, N. T. Jui, J. Am. Chem. Soc., 2019, 141, 4147-4153.

DOI: 10.1021/jacs.9b01077

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A unique combination of organic catalysts promotes the transfer of electrons and hydrogen atoms in a mild, modular, and practical direct hydroarylation of vinyl amine derivatives with a wide range of aryl halides (including aryl chlorides). This general and highly chemoselective protocol delivers a broad range of arylethylamine products with complete regiocontrol.

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Key Words

arylation, amines, photochemistry, organocatalysis

ID: J48-Y2019