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Construction of Benzofuran-3(2H)-one Scaffolds with a Quaternary Center via Rh/Co Relay Catalyzed C-H Functionalization/Annulation of N-Aryloxyacetamides and Propiolic Acids

Wen-Kui Yuan, Ming-Hui Zhu, Rui-Sen Geng, Guang-Yi Ren, Lin-Bao Zhang*, Li-Rong Wen*, Ming Li*

*College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P.R. China, Email:,,

W.-K. Yuan, M.-H. Zhu, R.-S. Geng, G.-Y. Ren, L.-B. Zhang, L.-R. Wen, M. Li, Org. Lett., 2019, 21, 1654-1658.

DOI: 10.1021/acs.orglett.9b00181

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A Rh/Co relay catalyzed C-H functionalization/annulation of N-aryloxyacetamides with propiolic acids provides valuable benzofuran-3(2H)-one scaffolds with a quaternary center in good yields.

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Key Words

benzofuran-3(2H)-ones, oxygen

ID: J54-Y2019