Synthesis of Imidazolidin-2-ones and Imidazol-2-ones via Base-Catalyzed Intramolecular Hydroamidation of Propargylic Ureas under Ambient Conditions
Alessandra Casnati, Antonio Perrone, Paolo P. Mazzeo, Alessia Bacchi, Raffaella Mancuso, Bartolo Gabriele, Raimondo Maggi, Giovanni Maestri Elena Motti, András Stirling*, Nicola Della Ca'*
*Research Centre for Natural Sciences, Budapest, Hungary; University of Parma, 43124 Parma, Italy,
Email: stirling.andras
ttk.mta.hu, nicola.dellacaunipr.it
A. Casnati, A. Perrone, P. P. Mazzeo, A. Bacchi, R. Mancuso, B. Gabriele, R. Maggi, G. M. E. Motti, A. Stirling, N. Della Ca', J. Org. Chem., 2019, 84, 3477-3490.
DOI: 10.1021/acs.joc.9b00064
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Abstract
The phosphazene base BEMP catalyzes an intramolecular hydroamidation of propargylic ureas to provide imidazolidin-2-ones and imidazol-2-ones with excellent chemo- and regioselectivities under ambient conditions and short reaction times.
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Key Words
imidazolidin-2-ones, organocatalysis
ID: J42-Y2019
