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Copper-Catalyzed Oxy-aminomethylation of Diazo Compounds with N,O-Acetals

Jianliang Yu, Long Chen, Jiangtao Sun*

*Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, P.R. China, Email:

J. Yu, L. Chen, J. Sun, Org. Lett., 2019, 21, 1664-1667.

DOI: 10.1021/acs.orglett.9b00203

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A copper-catalyzed oxy-aminomethylation reaction of diazo compounds with readily available N,O-acetals provides α-hydroxy-β2-amino acid derivatives with quaternary carbon centers in good yields.

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Key Words

β-Amino Acids, Hydroxylation

ID: J54-Y2019