Metal-Free Synthesis of 2-Arylbenzothiazoles from Aldehydes, Amines, and Thiocyanate

Amrita Dey, Alakananda Hajra*

*Department of Chemistry, Visva-Bharati (A Central University), Santiniketan 731235, India, Email: alakananda.hajravisva-bharati.ac.in

A. Dey, A. Hajra, Org. Lett., 2019, 21, 1686-1689.

DOI: 10.1021/acs.orglett.9b00245

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Abstract

A highly efficient reaction of readily available aromatic amines, benzaldehydes, and NH₄SCN as a sulfur source provides 2-arylbenzothiazoles with wide functional group compatibility in good yields via an iodine-mediated oxidative annulation.

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Key Words

benzothiazoles, iodine, multicomponent reactions

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ID: J54-Y2019