Metal-Free Method for Direct Synthesis of Functionalized β-Ketoenamines
Xiaobao Zeng, Chulong Liu, Weiguang Yang, Yunxiang Weng, Xinyan Wang*, Yuefei Hu*
*Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China, Email: wangxinyanmail.tsinghua.edu.cn, yfhmail.tsinghua.edu.cn
X. Zeng, C. Liu, W. Yang, Y. Weng, X. Wang, Y. Hu, J. Org. Chem., 2019, 84, 3656-3661.
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A BF3ˇOEt2-catalyzed cyclization of 1-iodoalkyne and α-keto acid followed by an amine-mediated ring-opening enable a metal-free direct synthesis of β-ketoenamines in one pot. The reaction tolerates transition metal-sensitive functional groups.
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