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Chiral Cyclopentadienyl Cobalt(III) Complexes Enable Highly Enantioselective 3d-Metal-Catalyzed C-H Functionalizations

Kristers Ozols, Yun-Suk Jang, Nicolai Cramer*

*Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland, Email: nicolai.cramerepfl.ch

K. Ozols, Y.-S. Jang, N. Cramer, J. Am. Chem. Soc., 2019, 141, 5675-5680.

DOI: 10.1021/jacs.9b02569



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Abstract

Asymmetric C-H functionalization in the presence of cobalt(III)-complexes equipped with trisubstituted chiral cyclopentadienyl ligands enables the synthesis of dihydroisoquinolones from N-chlorobenzamides with a broad range of alkenes. The transformation proceeds with excellent enantioselectivities and high regioselectivities.


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Key Words

3,4-dihydroisoquinolones


ID: J48-Y2019