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Nickel-Catalyzed Carboxylation of Aryl and Heteroaryl Fluorosulfates Using Carbon Dioxide

Cong Ma, Chuan-Qi Zhao, Xue-Tao Xu, Zhao-Ming Li, Xiang-Yang Wang, Kun Zhang, Tian-Sheng Mei*

*Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China, Email:

C. Ma, C.-Q. Zhao, X.-T. Xu, Z.-M. Li, X.-Y. Wang, K. Zhang, T.-S. Mei, Org. Lett., 2019, 21, 2464-2467.

DOI: 10.1021/acs.orglett.9b00836 (free Supporting Information)

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Nickel-catalyzed carboxylation of aryl fluorosulfates and heteroaryl fluorosulfates with CO2 provides arene carboxylic acids in very good yields under mild conditions. In addition, a one-pot phenol fluorosulfation/carboxylation was developed.

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Key Words

carboxylation, manganese

ID: J54-Y2019