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Transition-Metal-Free One-Step Synthesis of Ynamides

Xianzhu Zeng, Yongliang Tu, Zhenming Zhang, Changming You, Jiao Wu, Zhiying Ye, Junfeng Zhao*

*College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, People's Republic of China, Email:

X. Zeng, Y. Tu, Z. Zhang, C. You, J. Wu, Z. Ye, J. Zhao, J. Org. Chem., 2019, 84, 4458-4466.

DOI: 10.1021/acs.joc.8b03192

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A robust transition-metal-free reaction of sulfonamides and (Z)-1,2-dichloroalkenes or alkynyl chlorides enables the synthesis of internal and terminal ynamides. The reaction tolerates various functional groups.

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Key Words

sulfonamides, carbamates

ID: J42-Y2019