Copper-Catalyzed Decarboxylative N-Arylation of Indole-2-carboxylic Acids
Yan Zhang, Zhe-Yao Hu, Xin-Chang Li, Xun-Xiang Guo*
*Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, P. R. of China, Email: xunxiang_guosjtu.edu.cn
Y. Zhang, Z.-Y. Hu, X.-C. Li, X.-X. Guo, Synthesis, 2019, 51, 1803-1808.
A decarboxylative N-arylation of indole-2-carboxylic acids with aryl halides proceeds efficiently in the presence of Cu2O as the catalyst to give the corresponding N-aryl indoles in high yields. This method shows good functional group tolerance.
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