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Copper-Catalyzed Decarboxylative N-Arylation of Indole-2-carboxylic Acids

Yan Zhang, Zhe-Yao Hu, Xin-Chang Li, Xun-Xiang Guo*

*Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, P. R. of China, Email:

Y. Zhang, Z.-Y. Hu, X.-C. Li, X.-X. Guo, Synthesis, 2019, 51, 1803-1808.

DOI: 10.1055/s-0037-1611946


A decarboxylative N-arylation of indole-2-carboxylic acids with aryl halides proceeds efficiently in the presence of Cu2O as the catalyst to give the corresponding N-aryl indoles in high yields. This method shows good functional group tolerance.

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Key Words

indole-2-carboxylic acids, indoles, N-arylation, copper, decarboxylation, synthetic methods

ID: J66-Y2019