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Cu(OTf)2-Promoted 1,4-Addition of Alkyl Bromides to Dehydroalanine

Jung-Ah Shin, Jiheon Kim, Hongsoo Lee, Sura Ha, Hee-Yoon Lee*

*Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea, Email:

J.-A. Shin, J. Kim, H. Lee, S. Ha, H.-Y. Lee, J. Org. Chem., 2019, 84, 4558-4565.

DOI: 10.1021/acs.joc.9b00369

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A Zn/Cu(OTf)2-mediated addition of alkyl bromides to dehydroalanine (Dha) derivatives including dipeptides and tripeptides provides selective and biocompatible access to various amino acid units in good to high yields in an aqueous medium.

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Key Words

α-Amino Acids, Zinc

ID: J42-Y2019