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Ni-catalyzed Reductive Deaminative Arylation at sp3 Carbon Centers

Raul Martin-Montero, Veera Reddy Yatham, Hongfei Yin, Jacob Davies, Ruben Martin*

*Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Pa´sos Catalans 16, 43007 Tarragona, Spain, Email:

R. Martin-Montero, Y. R. Yatham, H. Yin, J. Davies, R. Martin, Org. Lett., 2019, 21, 2947-2951.

DOI: 10.1021/acs.orglett.9b01016

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An operationally simple and user-friendly Ni-catalyzed reductive deaminative arylation at unactivated sp3 carbon centers exhibits an excellent chemoselectivity profile and broad substrate scope. The reaction has also been used in the context of late-stage functionalization to reliably generate structure diversity with amine-containing drugs.

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Key Words

alkylation, manganese

ID: J54-Y2019