Virtues of Volatility: A Facile Transesterification Approach to Boronic Acids
Stefan P. A. Hinkes, Christian D. P. Klein*
*Institute of Pharmacy and Molecular Biotechnology (IPMB), Medicinal Chemistry, University of Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany,
Email: c.klein
uni-heidelberg.de
S. P. A. Hinkes, C. D. P. Klein, Org. Lett., 2019, 21, 3048-3052.
DOI: 10.1021/acs.orglett.9b00584
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Abstract
The deprotection of boronic esters can be performed under mild conditions in the presence of methylboronic acid. The reaction provides high yields, and eliminates cumbersome and problematic purification steps due to the high volatility of methylboronic acid and its diol esters.
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Key Words
ID: J54-Y2019
