Organic Chemistry Portal



Virtues of Volatility: A Facile Transesterification Approach to Boronic Acids

Stefan P. A. Hinkes, Christian D. P. Klein*

*Institute of Pharmacy and Molecular Biotechnology (IPMB), Medicinal Chemistry, University of Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany, Email:

S. P. A. Hinkes, C. D. P. Klein, Org. Lett., 2019, 21, 3048-3052.

DOI: 10.1021/acs.orglett.9b00584

see article for more reactions


The deprotection of boronic esters can be performed under mild conditions in the presence of methylboronic acid. The reaction provides high yields, and eliminates cumbersome and problematic purification steps due to the high volatility of methylboronic acid and its diol esters.

see article for more examples

Key Words

boronic acids

ID: J54-Y2019