Heterogeneous Copper(I)-Catalyzed Cascade Addition–Oxidative Cyclization of Nitriles with 2-Aminopyridines or Amidines: Efficient and Practical Synthesis of 1,2,4-Triazoles
Jianhui Xia, Xue Huang, Mingzhong Cai*
*Ministry of Education and College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. of China,
Email: mzcai
jxnu.edu.cn
J. Xia, X. Huang, M. Cai, Synthesis, 2019, 51, 2014-2022.
DOI: 10.1055/s-0037-1611712
Abstract
A cascade addition-oxidative cyclization of nitriles with 2-aminopyridines or amidines was achieved in the presence of 1,10-phenanthroline-functionalized MCM-41-supported copper(I) complex [Phen-MCM-41-CuBr] as the heterogeneous and recyclable catalyst and air as the oxidant. The approach provides a wide range of 1,2,4-triazole derivatives in high yields.
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Key Words
copper, 1,2,4-triazoles, oxidative cyclization, oxygen, heterogeneous catalysis, cascade reaction
ID: J66-Y2019
