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Heterogeneous Copper(I)-Catalyzed Cascade Addition–Oxidative Cyclization of Nitriles with 2-Aminopyridines or Amidines: Efficient and Practical Synthesis of 1,2,4-Triazoles

Jianhui Xia, Xue Huang, Mingzhong Cai*

*Ministry of Education and College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. of China, Email:

J. Xia, X. Huang, M. Cai, Synthesis, 2019, 51, 2014-2022.

DOI: 10.1055/s-0037-1611712


A cascade addition-oxidative cyclization of nitriles with 2-aminopyridines or amidines was achieved in the presence of 1,10-phenanthroline-functionalized MCM-41-supported copper(I) complex [Phen-MCM-41-CuBr] as the heterogeneous and recyclable catalyst and air as the oxidant. The approach provides a wide range of 1,2,4-triazole derivatives in high yields.

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Key Words

copper, 1,2,4-triazoles, oxidative cyclization, oxygen, heterogeneous catalysis, cascade reaction

ID: J66-Y2019