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Synthesis of 4-Oxoisoxazoline N-Oxides via Pd-Catalyzed Cyclization of Propargylic Alcohols with tert-Butyl Nitrite

Kai-Wen Feng, Yong-Liang Ban, Pan-Feng Yuan, Wen-Long Lei, Qiang Liu*, Ran Fang*

*State Key Laboratory of Applied Organic Chemistry, Lanzhou University, 222 South Tianshui Road, Lanzhou 730000, P.R. China, Email:,

K.-W. Feng, Y.-L. Ban, P.-F. Yuan, W.-L. Lei, Q. Liu, R. Fang, Org. Lett., 2019, 21, 3131-3135.

DOI: 10.1021/acs.orglett.9b00811

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Pd(OAc)2 catalyzes a cyclization of propargylic alcohols with tert-butyl nitrite at room temperature to provide 4-oxoisoxazoline N-oxides in good yields under mild conditions.

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Key Words

4-oxoisoxazolines, N-heterocycles

ID: J54-Y2019