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A Highly Active PN3 Manganese Pincer Complex Performing N-Alkylation of Amines under Mild Conditions

Leonard Homberg, Alexander Roller, Kai C. Hultzsch*

*University of Vienna, Faculty of Chemistry, Institute of Chemical Catalysis, Währinger Straße 38, 1090 Vienna, Austria, Email: kai.hultzschunivie.ac.at

L. Homberg, A. Roller, K. C. Hultzsch, Org. Lett., 2019, 21, 3142-3147.

DOI: 10.1021/acs.orglett.9b00832 (free Supporting Information)



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Abstract

A highly active Mn(I) pincer catalyst enables an atom-economic and highly efficient N-alkylation of amines with alcohols utilizing the borrowing hydrogen methodology. A broad range of anilines and more challenging aliphatic amines were alkylated with primary and secondary alcohols. The reaction offers low catalyst loadings and mild reaction conditions.

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Key Words

benzylic amines, protection


ID: J54-Y2019