Cascade Process for Direct Transformation of Aldehydes (RCHO) to Nitriles (RCN) Using Inorganic Reagents NH₂OH/Na₂CO₃/SO₂F₂ in DMSO

Wan-Yin Fang, Hua-Li Qin*

*School of Chemistry, Chemical Engineering, and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan 430070, P. R. China, Email: qinhualiwhut.edu.cn

W.-Y. Fang, H.-L. Qin, J. Org. Chem., 2019, 84, 5803-5812.

DOI: 10.1021/acs.joc.8b03164

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Abstract

The use of inorganic reagents (NH₂OH/Na₂CO₃/SO₂F₂) in DMSO enables a simple and practical transformation of readily available, inexpensive, and abundant aldehydes to highly valuable nitriles in a pot, atom, and step-economical manner without transition metals. The reaction offers a wide substrate scope and great functional group tolerability.

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Key Words

nitriles

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ID: J42-Y2019