Cascade Process for Direct Transformation of Aldehydes (RCHO) to Nitriles (RCN) Using Inorganic Reagents NH2OH/Na2CO3/SO2F2 in DMSO
Wan-Yin Fang, Hua-Li Qin*
*School of Chemistry, Chemical Engineering, and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan 430070, P. R. China, Email: qinhualiwhut.edu.cn
W.-Y. Fang, H.-L. Qin, J. Org. Chem., 2019, 84, 5803-5812.
The use of inorganic reagents (NH2OH/Na2CO3/SO2F2) in DMSO enables a simple and practical transformation of readily available, inexpensive, and abundant aldehydes to highly valuable nitriles in a pot, atom, and step-economical manner without transition metals. The reaction offers a wide substrate scope and great functional group tolerability.
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