Electrochemical Radical Formyloxylation-Bromination, -Chlorination, and -Trifluoromethylation of Alkenes

Xiang Sun, Hong-Xing Ma, Tian-Sheng Mei, Ping Fang*, Yulai Hu*

*Shanghai Institute of Organic Chemistry, 345 Lingling Lu, Shanghai 200032; Northwest Normal University, 967 Anning East Road, Lanzhou 730070, China, Email: pfangsioc.ac.cn, huylnwnu.edu.cn

X. Sun, H.-X. Ma, T.-S. Mei, P. Fang, Y. Hu, Org. Lett., 2019, 21, 3167-3171.

DOI: 10.1021/acs.orglett.9b00867

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Abstract

A green, oxidant-free electrochemical method enables radical bromination, chlorination and trifluoromethylation-formyloxylation of various alkenes with readily available halogen radical (NaCl, NaBr), and trifluoromethyl radical (CF₃SO₂Na) sources in DMF as formyloxylation reagent in an undivided electrochemical cell.

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Key Words

electrochemistry, bromination, chlorination, trifluoromethylation

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ID: J54-Y2019