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Synthesis of Alkynyl Sulfides by Copper-Catalyzed Thiolation of Terminal Alkynes Using Thiosulfonates

Kazuya Kanemoto, Suguru Yoshida*, Takamitsu Hosoya*

*Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan, Email:,

K. Kanemoto, S. Yoshida, T. Hosoya, Org. Lett., 2019, 21, 3172-3177.

DOI: 10.1021/acs.orglett.9b00875

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A mild and odorless copper-catalyzed thiolation of terminal alkynes with thiosulfonates provides convenient access to a wide variety of alkynyl sulfides and sulfur-containing heterocycles via a subsequent iodocyclization.

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Key Words

alkynyl sulfides

ID: J54-Y2019