One-Pot Synthesis of Less Accessible N-Boc-Propargylic Amines through BF3-Catalyzed Alkynylation and Allylation Using Boronic Esters
Kento Yasumoto, Taichi Kano*, Keiji Maruoka*
*Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan,
Email: kanokuchem.kyoto-u.ac.jp, maruoka
kuchem.kyoto-u.ac.jp
K. Yasumoto, T. Kano, K. Maruoka, Org. Lett., 2019, 21, 3214-3217.
DOI: 10.1021/acs.orglett.9b00931
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Abstract
A BF3-mediated in situ generation of alkynyl imines followed by alkynylation or allylation with boronic esters enables an efficient synthesis of α-alkynyl- or α-allyl-substituted N-Boc-propargylic amines in good yields under mild conditions.
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Key Words
propargylamines (C-C coupling, C-N coupling), multicomponent reactions
ID: J54-Y2019