One-Pot Three-Component Strategy for Polysubstituted 2-Aminothiazoles via Ring Opening of α-Nitro Epoxides

Yue Zhu, Wenteng Chen, Donghong Zhao, Guolin Zhang*, Yongping Yu*

*Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. of China, Email: guolinzhangzju.edu.cn, yyuzju.edu.cn

Y. Zhu, W. Chen, D. Zhao, G. Zhang, Y. Yu, Synthesis, 2019, 51, 2023-2029.

DOI: 10.1055/s-0037-1612101

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Abstract

A one-pot three-component reaction of α-nitro epoxides, potassium thiocyanate, and primary amines provides polysubstituted 2-aminothiazoles in a smooth, highly efficient, and eco-friendly manner with good yields.

see article for more examples

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One-Pot Three-Component Strategy for Functionalized 2-Aminoimidazoles via Ring Opening of α-Nitro Epoxides

X. Guo, W. Chen, B. Chen, W. Huang, W. Qi, G. Zhang, Y. Yu, Org. Lett., 2015, 17, 1157-1159.

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Key Words

2-aminothiazoles, thiazoles, nitro epoxides, potassium thiocyanate, anilines, one-pot synthesis

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ID: J66-Y2019