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Electrochemical Synthesis Strategy for Cvinyl-CF3 Compounds through Decarboxylative Trifluoromethylation

Huanliang Hong, Yibiao Li, Lu Chen, Bin Li, Zhongzhi Zhu, Xiuwen Chen, Ling Chen, Yubing Huang*

*School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China, Email:

H. Hong, Y. Li, L. Chen, B. Li, Z. Zhu, X. Chen. L. Chen, Y. Huang, J. Org. Chem., 2019, 84, 5980-5986.

DOI: 10.1021/acs.joc.9b00766 (free Supporting Information)


An electro-oxidative strategy enables an efficient decarboxylative trifluoromethylation of α,β-unsaturated carboxylic acids using the Langlois reagent as a trifluoromethyl precursor. Under catalyst-free and external oxidant-free conditions, a series of trifluoromethylated styrenes are obtained with a high regioselectivity in good yields.

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Key Words

trifluoromethylation, electrochemistry

ID: J42-Y2019