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Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2-Aminophenyl Ketones and 2-Aminobenzamides with Amines

Pandula T. Kirinde Arachchige, Chae S. Yi*

*Department of Chemistry, Marquette University, Milwaukee, Wisconsin 53201-1881 United States, Email: chae.yimarquette.edu

P. T. K. Arachchige, C. S. Yi, Org. Lett., 2019, 21, 3337-3341.

DOI: 10.1021/acs.orglett.9b01082


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Abstract

An in situ formed ruthenium catalyst enables a highly selective dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form quinazoline products. The deaminative coupling reaction of 2-aminobenzamides with amines provides quinazolinone products. The reactions work without using any reactive reagents or forming any toxic byproducts.


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Key Words

quinazolines


ID: J54-Y2019