Iridium(I)-Catalyzed C-C and C-N Bond Formation Reactions via the Borrowing Hydrogen Strategy

Sertaç Genç, Burcu Arslan, Süleyman Gülcemal*, Salih Günnaz, Bekir Çetinkaya, Derya Gülcemal*

*Chemistry Department, Ege University, Bornova, 35100 Izmir, Turkey, Email: suleyman.gulcemalege.edu.tr, derya.gulcemalege.edu.tr

S. Genç, B. Arslan, S. Gülcemal, S. Günnaz, B. Çetinkaya, D. Gülcemal, J. Org. Chem., 2019, 84, 6286-6297.

DOI: 10.1021/acs.joc.9b00632

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Abstract

Very low loadings of iridium(I) complexes having an imidazol-2-ylidene ligand with benzylic wingtips efficiently catalyze the β-alkylation of secondary alcohols with primary alcohols and acceptorless dehydrogenative formation of quinolines from 2-aminobenzyl alcohol and ketones through a borrowing hydrogen pathway to provide the desired products in good yields.

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Key Words

β-alkylation, benzylation

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ID: J42-Y2019