Nickel-Catalyzed Decarboxylation of Aryl Carbamates for Converting Phenols into Aromatic Amines

Akihiro Nishizawa, Tsuyoshi Takahira, Kosuke Yasui, Hayato Fujimoto, Tomohiro Iwai*, Masaya Sawamura*, Naoto Chatani*, Mamoru Tobisu*

*Hokkaido University, Sapporo 060-0810; Osaka University, Suita, Osaka 565-0871, Japan, Email: iwai-tsci.hokudai.ac.jp, sawamurasci.hokudai.ac.jp, chatanichem.eng.osaka-u.ac.jp, tobisuchem.eng.osaka-u.ac.jp

A. Nishizawa, T. Takahira, K. Yasui, H. Fujimoto, T. Iwai, M. Sawamura, N. Chatani, M. Tobisu, J. Am. Chem. Soc., 2019, 141, 7262-7265.

DOI: 10.1021/jacs.9b02751

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Abstract

A nickel-catalyzed decarboxylation reaction of aryl carbamates forms aromatic amines with carbon dioxide as the only byproduct. As this amination proceeds in the absence of free amines, a range of functionalities, including formyl groups, are compatible.

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PS-DPPBz

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Key Words

amination

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ID: J48-Y2019