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Exploration of Aryl Phosphates in Palladium-Catalyzed Mono-α-arylation of Aryl and Heteroaryl Ketones

Xiangmeng Chen, Zicong Chen, Chau Ming So*

*Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, Email:

X. Chen, Z. Chen, C. M. So, J. Org. Chem., 2019, 84, 6337-6346.

DOI: 10.1021/acs.joc.9b00669 (free Supporting Information)

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A catalyst system, consisting of [Pd(2-butenyl)Cl]2 and MorDalPhos, exhibited high catalytic reactivity toward a mono-α-arylation of aryl and heteroaryl ketones with aryl phosphates. A wide range of aryl phosphates were efficiently coupled with aryl and heteroaryl ketones with good selectivity and very good yields.

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ID: J42-Y2019