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Silver-Catalyzed Reduction of Quinolines in Water

Yan Wang, Baobiao Dong, Zikun Wang*, Xuefeng Cong, Xihe Bi*

*Department of Chemistry, Northeast Normal University, Changchun 130024, China, Email:,

Y. Wang, B. Dong, Z. Wang, X. Cong, X. Bi, Org. Lett., 2019, 21, 3631-3634.

DOI: 10.1021/acs.orglett.9b01055

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A ligand- and base-free silver-catalyzed reduction of quinolines provides a facile, environmentally friendly, and practical access to various 1,2,3,4-tetrahydroquinoline derivatives at room temperature. Mechanistic studies revealed that the effective reducing species was Ag-H.

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Key Words

tetrahydroquinolines, phenylsilane

ID: J54-Y2019