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Potassium tert-Butoxide-Mediated Condensation Cascade Reaction: Transition Metal-Free Synthesis of Multisubstituted Aryl Indoles and Benzofurans

Pengfei Yang, Weiyan Xu, Rongchao Wang, Min Zhang, Chunsong Xie, Xiaofei Zeng, Min Wang*

*College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, P. R. China, Email: mwanghznu.edu.cn

P. Yang, W. Yu, R. Wang, M. Zhang, C. Xie, X. Zeng, M. Wang, Org. Lett., 2019, 21, 3658-3662.

DOI: 10.1021/acs.orglett.9b01093 (free Supporting Information)


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Abstract

A transition metal-free, tert-butoxide-mediated condensation reaction enables an efficient and facile synthesis of valuable disubstituted 2-aryl indoles and benzofurans in good yields from N- or O-benzyl benzaldehydes using dimethyl sulfoxide as a carbon source. The methodology offers a wide functional group tolerance.

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Key Words

indoles


ID: J54-Y2019