Potassium tert-Butoxide-Mediated Condensation Cascade Reaction: Transition Metal-Free Synthesis of Multisubstituted Aryl Indoles and Benzofurans
Pengfei Yang, Weiyan Xu, Rongchao Wang, Min Zhang, Chunsong Xie, Xiaofei Zeng, Min Wang*
*College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, P. R. China,
Email: mwang
hznu.edu.cn
P. Yang, W. Yu, R. Wang, M. Zhang, C. Xie, X. Zeng, M. Wang, Org. Lett., 2019, 21, 3658-3662.
DOI: 10.1021/acs.orglett.9b01093
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Abstract
A transition metal-free, tert-butoxide-mediated condensation reaction enables an efficient and facile synthesis of valuable disubstituted 2-aryl indoles and benzofurans in good yields from N- or O-benzyl benzaldehydes using dimethyl sulfoxide as a carbon source. The methodology offers a wide functional group tolerance.
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Key Words
ID: J54-Y2019
