Palladium/XuPhos-Catalyzed Enantioselective Carboiodination of Olefin-Tethered Aryl Iodides
Zhan-Ming Zhang, Bing Xu, Lizuo Wu, Lujia Zhou, Danting Ji, Yu Liu, Zhiming Li*, Junliang Zhang*
*Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai, 200438, China, Email: zmlifudan.edu.cn, junliangzhangfudan.edu.cn
Z.-M. Zhang, B. Xu, L. Wu, L. Zhou, D. Ji, Y. Liu, Z. Li, H. Zhang, J. Am. Chem. Soc., 2019, 141, 8110-8115.
DOI: 10.1021/jacs.9b04332 (free Supporting Information)
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A highly enantioselective palladium-catalyzed iodine atom transfer cycloisomerization of olefin-tethered aryl iodides provides optically active 2,3-dihydrobenzofurans, indolines and chromanes bearing an alkyl iodide group in good yields. The reaction offers use of readily available starting materials, a broad substrate scope, high selectivity, and mild conditions.
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