Site-Selective Mono-Oxidation of 1,2-Bis(boronates)
Lu Yan, James P. Morken*
*Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States,
Email: morken
bc.edu
L. Yan, J. P. Morken, Org. Lett., 2019, 21, 3760-3763.
DOI: 10.1021/acs.orglett.9b01204
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Abstract
The use of N-oxides in butanol as solvent enables a site-selective oxidation of vicinal bis(boronates) with good efficiency and selectivity across a range of substrates to provide 2-hydro-1-boronic esters, which are shown to be versatile intermediates in the synthesis of chiral building blocks.
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Key Words
boration, hydroxylation, NMO, organocatalysis
ID: J54-Y2019
