Nickel-Catalyzed 1,2-Arylboration of Vinylarenes
Wang Wang, Chao Ding, Hailiang Pang, Guoyin Yin*
*The Institute for Advanced Studies, Wuhan University, Wuhan, Hubei 430072, China,
Email: yinguoyin
whu.edu.cn
W. Wang, C. Ding, H. Pang, G. Yin, Org. Lett., 2019, 21, 3968-3971.
DOI: 10.1021/acs.orglett.9b01120
Abstract
A nickel-catalyzed 1,2-arylboration of vinylarenes with aryl halides provides various 2-boryl-1,1-diarylalkanes, which constitute a class of significant pharmacophores, in the presence of bis(pinacolato)diboron under mild reaction conditions. This three-component cascade reaction exhibits good functional group tolerance and excellent chemo- and stereoselectivity.
see article for more examples
Key Words
boration, arylation, multicomponent reactions
ID: J54-Y2019
