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Nickel-Catalyzed 1,2-Arylboration of Vinylarenes

Wang Wang, Chao Ding, Hailiang Pang, Guoyin Yin*

*The Institute for Advanced Studies, Wuhan University, Wuhan, Hubei 430072, China, Email:

W. Wang, C. Ding, H. Pang, G. Yin, Org. Lett., 2019, 21, 3968-3971.

DOI: 10.1021/acs.orglett.9b01120


A nickel-catalyzed 1,2-arylboration of vinylarenes with aryl halides provides various 2-boryl-1,1-diarylalkanes, which constitute a class of significant pharmacophores, in the presence of bis(pinacolato)diboron under mild reaction conditions. This three-component cascade reaction exhibits good functional group tolerance and excellent chemo- and stereoselectivity.

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Key Words

boration, arylation, multicomponent reactions

ID: J54-Y2019