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Copper-Catalyzed Oxidative [4 + 2]-Cyclization Reaction of Glycine Esters with Anthranils: Access to 3,4-Dihydroquinazolines

Jie Ren, Chao Pi*, Yangjie Wu, Xiuling Cui*

*Department of Chemistry, Zhengzhou University, Zhengzhou 450052, P. R. China, Email:,

J. Ren, C. Pi, Y. Wu, X. Cui, Org. Lett., 2019, 21, 4067-4071.

DOI: 10.1021/acs.orglett.9b01246


A convenient copper-catalyzed oxidative cross-dehydrogenative [4 + 2]-cyclization of glycine derivatives with anthranils enables an efficient and atom-economical synthesis of various 3,4-dihydroquinazolines. The reaction offers high efficiency and wide substrate tolerance.

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Key Words

benzo-fused N-heterocyles, benzoyl peroxide

ID: J54-Y2019