A Microwave-Assisted SmI2-Catalyzed Direct N-Alkylation of Anilines with Alcohols
Jitendra Gour, Srikanth Gatadi, Satyaveni Malasala, Madhavi Venkata Yaddanpudi, Srinivas Nanduri*
*Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India,
Email: nandurisrini92
gmail.com
J. Gour, S. Gatadi, S. Malasala, M. V. Yaddanpudi, S. Nanduri, J. Org. Chem., 2019, 84, 7488-7494.
DOI: 10.1021/acs.joc.9b00717 (free Supporting Information)
Abstract
A monobenzylation of aromatic amines with benzylic alcohols in good yields proceeds under MW conditions in the presence of SmI2 as a catalyst with the generation of water as the sole byproduct. This reaction offers a broad substrate scope and good functional-group tolerance.
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Key Words
microwave synthesis, benzylic amines, aromatic amines
ID: J42-Y2019
