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A Microwave-Assisted SmI2-Catalyzed Direct N-Alkylation of Anilines with Alcohols

Jitendra Gour, Srikanth Gatadi, Satyaveni Malasala, Madhavi Venkata Yaddanpudi, Srinivas Nanduri*

*Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India, Email: nandurisrini92gmail.com

J. Gour, S. Gatadi, S. Malasala, M. V. Yaddanpudi, S. Nanduri, J. Org. Chem., 2019, 84, 7488-7494.

DOI: 10.1021/acs.joc.9b00717 (free Supporting Information)


Abstract

A monobenzylation of aromatic amines with benzylic alcohols in good yields proceeds under MW conditions in the presence of SmI2 as a catalyst with the generation of water as the sole byproduct. This reaction offers a broad substrate scope and good functional-group tolerance.

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Key Words

microwave synthesis, benzylic amines, aromatic amines


ID: J42-Y2019