Visible-Light Induction/Brønsted Acid Catalysis in Relay for the Enantioselective Synthesis of Tetrahydroquinolines
Wenhui Xiong, Shan Li, Bo Fu, Jinping Wang*, Qiu-An Wang*, Wen Yang*
*College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, People’s Republic of China,
Email: jinpingwang1985
126.com, wangqahnu.edu.cn, yangwenhnu.edu.cn
W. Xiong, S. Li, B. Fu, J. Wang, Q.-A. Wang, W. Yang, Org. Lett., 2019, 21, 4173-4176.
DOI: 10.1021/acs.orglett.9b01354
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Abstract
The combination of Brønsted acid catalysis with visible-light induction enables a highly enantioselective synthesis of 2-substituted tetrahydroquinolines from 2-aminoenones through a relay visible-light-induced cyclization/chiral phosphoric acid-catalyzed transfer hydrogenation reaction.
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Key Words
tetrahydroquinolines, Hantzsch ester, organocatalysis, photochemistry
ID: J54-Y2019
