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Direct Intermolecular Anti-Markovnikov Hydroazidation of Unactivated Olefins

Hongze Li, Shou-Jie Shen, Cheng-Liang Zhu, Hao Xu*

*Department of Chemistry, Georgia State University, 100 Piedmont Avenue SE, Atlanta Georgia 30303, United States, Email: hxugsu.edu

H. Li, S.-J. Shen, C.-L. Zhu, H. Xu, J. Am. Chem. Soc., 2019, 141, 9415-9421.

DOI: 10.1021/jacs.9b04381 (free Supporting Information)


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Abstract

A direct intermolecular anti-Markovnikov hydroazidation method for unactivated olefins is promoted by a catalytic amount of bench-stable benziodoxole at ambient temperature. This method facilitates previously difficult, direct addition of hydrazoic acid across a wide variety of unactivated olefins.

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Key Words

alkyl azides


ID: J48-Y2019