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Synthesis of 2-Aminoindoles through Gold-Catalyzed C-H Annulations of Sulfilimines with N-Arylynamides

Xianhai Tian, Lina Song, Matthias Rudolph, Frank Rominger, A. Stephen K. Hashmi*

*Institut für Organische Chemie, Heidelberg University, Im Neuenheimer Feld 270, Heidelberg 69120, Germany, Email:

X. Tian, L. Song, M. Rudolph, F. Rominger, A. S. K. Hashmi, Org. Lett., 2019, 21, 4327-4330.

DOI: 10.1021/acs.orglett.9b01501

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A gold-catalyzed C-H annulation of sulfilimines with N-phenylynamides affords 2-aminoindoles bearing a variety of substitution patterns in high selectivities. This reaction offers a facile approach to biologically important 2-aminoindoles by using inexpensive and readily available starting materials.

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Key Words


ID: J54-Y2019