Formamide Catalysis Facilitates the Transformation of Aldehydes into Geminal Dichlorides
Peter Helmut Huy*
*Saarland University, Institute of Organic Chemistry, P. O. Box 151150, 66041 Saarbruecken, Germany,
Email: peter.huy
uni-saarland.de
P. H. Huy, Synthesis, 2019, 51, 2474-2483.
DOI: 10.1055/s-0037-1611798
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Abstract
Phthaloyl chloride as reagent and N-formylpyrrolidine as Lewis base catalyst enable a transformation of aldehydes into geminal dichlorides. This simple reaction offers mild reaction conditions, high levels of functional group compatibility, and scalability.
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Key Words
halogenation, organocatalysis, geminal dihalogenides, benzyl chlorides, Vilsmeier Haack reagent
ID: J66-Y2019
