Formamide Catalysis Facilitates the Transformation of Aldehydes into Geminal Dichlorides
Peter Helmut Huy*
*Saarland University, Institute of Organic Chemistry, P. O. Box 151150, 66041 Saarbruecken, Germany, Email: peter.huyuni-saarland.de
P. H. Huy, Synthesis, 2019, 51, 2474-2483.
DOI: 10.1055/s-0037-1611798 (free Supporting Information)
see article for more reactions
Phthaloyl chloride as reagent and N-formylpyrrolidine as Lewis base catalyst enable a transformation of aldehydes into geminal dichlorides. This simple reaction offers mild reaction conditions, high levels of functional group compatibility, and scalability.
see article for more examples