Organic Chemistry Portal



Formamide Catalysis Facilitates the Transformation of Aldehydes into Geminal Dichlorides

Peter Helmut Huy*

*Saarland University, Institute of Organic Chemistry, P. O. Box 151150, 66041 Saarbruecken, Germany, Email:

P. H. Huy, Synthesis, 2019, 51, 2474-2483.

DOI: 10.1055/s-0037-1611798

see article for more reactions


Phthaloyl chloride as reagent and N-formylpyrrolidine as Lewis base catalyst enable a transformation of aldehydes into geminal dichlorides. This simple reaction offers mild reaction conditions, high levels of functional group compatibility, and scalability.

see article for more examples

Key Words

halogenation, organocatalysis, geminal dihalogenides, benzyl chlorides, Vilsmeier Haack reagent

ID: J66-Y2019