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Sustainable Alkylation of Nitriles with Alcohols by Manganese Catalysis

Jannik C. Borghs, Mai Anh Tran, Jan Sklyaruk, Magnus Rueping*, Osama El-Sepelgy*

*Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany, Email:,

J. C. Borgh, M. A. Tran, J. Sklyaruk, M. Rueping, O. El-Sepelgy, J. Org. Chem., 2019, 84, 7927-7935.

DOI: 10.1021/acs.joc.9b00792

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A homogeneous nonprecious manganese catalyst enables a general and chemoselective catalytic alkylation of nitriles with naturally abundant alcohols. The reaction tolerates a wide range of functional groups and heterocyclic moieties and provides useful cyanoalkylated products with water as the only side product.

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Key Words


ID: J42-Y2019